Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
eMolecules Oakwood Chemical Trifluoroacetic acid commercial grade 3kg 596608271 105899 0 000 76-05-1 MFCD00004169 114 023 C2HF3O2
Oakwood Chemical Trifluoroacetic acid commercial grade 3kg 596608271 105899 0 000 76-05-1 MFCD00004169 114 023 C2HF3O2
Medchemexpress LLC Cl2e-SN38 TFA | 99.1% | 1855.95 | C89H117F3N14O26 | 5 MG
CL2E-SN-38 TFA is an antibody-drug conjugate (ADC) drug-linker consisting of an SN-38 payload attached via a CL2E linker in the trifluoroacetate (TFA) salt form. It is intended for preclinical research into ADCs, where SN-38 functions as a topoisomerase I inhibitor.
- Highly releasable and structurally stable antibody-SN-38 conjugate.
- Contains SN-38 payload, a topoisomerase I inhibitor.
- TFA salt form for improved solubility and handling.
- Available in small research quantities (5 MG).
- High purity suitable for preclinical ADC development.
Medchemexpress LLC 3-amino-4-(3-hexylphenylamino)-4-oxobutyl phosphonic acid | 909725-62-8 | 98.2% | 456.39 g/mol | C18H28F3N2O6P | 1 ML
W146 TFA is the trifluoroacetic acid salt of W146, a selective antagonist of the sphingosine-1-phosphate receptor 1 (S1PR1). It is supplied as a ready-to-use 10 mM solution in DMSO and as solid material for research applications, and is used in in vitro pharmacology and signaling studies to probe S1PR1-mediated pathways.
- Selective antagonist of sphingosine-1-phosphate receptor 1 (S1PR1).
- Reported EC50 of 398 nM.
- Supplied as 10 mM solution in DMSO (1 mL) and in multiple solid masses.
- Chemical identifiers: CAS 909725-62-8, formula C18H28F3N2O6P, MW 456.39 g/mol.
- Intended for research use only; not for human or clinical use.