Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
SIGMA ALDRICH FINE CHEMICALS BIOSCIENCES LC-MS TRIFLUOROACETIC ACID50ML
NC2952351 LC-MS TRIFLUOROACETIC ACID50ML
Medchemexpress LLC SJ1008030 TFA | 2863634-97-1 | 99.8% | 987.96 | 5 MG
SJ1008030 TFA is a JAK2 PROTAC that selectively degrades JAK2. It inhibits MHH-CALL-4 cell growth with an IC50 of 5.4 nM and can be utilized for leukemia research. The compound is composed of a JAK2 ligand, a Cereblon ligand, and a linker.
- Selective JAK2 PROTAC degrader.
- Inhibits MHH-CALL-4 cell growth with an IC50 of 5.4 nM.
- Can be used for leukemia research.
- Degrades JAKs, GSPT1, and IKZF1 in a dose-dependent manner in MHH-CALL-4 cells.
- Dose-dependently degrades JAK2 and GSPT1 protein in xenograft bone marrow SJBALL021415 cells, indicating inhibition of the JAK-STAT signaling pathway.
Medchemexpress LLC TL033 TFA | 2746343-70-2 | 98.1% | 1630.83 | 5 MG
TL033 TFA (HY-147340A) is a chemical compound with CAS number 2746343-70-2 and a molecular weight of 1630.83. This product is supplied as a light yellow to yellow solid with a high purity of 98.1% (HPLC). It requires specific storage conditions to maintain its integrity, ensuring reliability for research applications.
- CAS number: 2746343-70-2
- Purity (HPLC): 98.1%
- Molecular weight: 1630.83
- Appearance: Light yellow to yellow solid
- Recommended storage (solid): -20°C, sealed, away from moisture and light
- Storage in solvent: -80°C (6 months) or -20°C (1 month), sealed, away from moisture and light
Medchemexpress LLC Cyclorasin 9A5 (TFA) | 1 MG
Cyclorasin 9A5 (TFA) from MedChemExpress is a laboratory chemical intended for research use only. It is presented as a solid and is stable under recommended storage conditions, emphasizing careful handling and storage to maintain its integrity.
- Stable under recommended storage
- Keep sealed in cool, well-ventilated area, away from direct sunlight and ignition
- Powder storage: -80°C for 2 years, -20°C for 1 year
- Solution storage: -80°C for 6 months, -20°C for 1 month
- Ships at room temperature (less than 2 weeks)
- Not classified as hazardous
- Requires personal protective equipment (safety goggles, gloves, impervious clothing, respirator)
- Ensure adequate ventilation, safety shower, and eye wash station
Medchemexpress LLC Cys-PKHB1 TFA | 65.8% | 1487.88 | 1 MG
Cys-PKHB1 (Cys-txCD47) TFA is a peptide conjugated to PKHB1, which is a CD47 agonist peptide and a thrombospondin-1 peptide mimic with antitumor effects. This peptide induces mitochondrial alterations, ROS generation, intracellular Ca+ accumulation, and calcium-dependent cell death in breast cancer cells. It also induces immune system activation in breast cancer cells through immunogenic cell death.
- Peptide conjugated to PKHB1
- Acts as a CD47 agonist
- Functions as a thrombospondin-1 peptide mimic
- Induces mitochondrial alterations
- Promotes ROS generation
- Leads to intracellular Ca+ accumulation
- Causes calcium-dependent cell death in breast cancer cells
- Induces immune system activation in breast cancer cells
Medchemexpress LLC Gplgiagq tfa | 99.9% | 825.83 | 50 MG
GPLGIAGQ TFA is an MMP2-cleavable polypeptide used as a stimulus-sensitive linker in liposomal and micellar nanocarriers for MMP2-triggered tumor targeting. It can also be utilized to synthesize unique MMP2-targeted photosensitizers in photodynamic therapy (PDT). This product is for research use only.
- Used as a stimulus-sensitive linker in liposomal and micellar nanocarriers for tumor targeting
- Can be utilized to synthesize unique MMP2-targeted photosensitizers in photodynamic therapy (PDT)
- For research use only
- MMP2-cleavable polypeptide
- Target: MMP2
- Molecular weight: 825.83
- Formula: C33H54F3N9O12
- Appearance: solid, white to off-white
- Sequence: Gly-Pro-Leu-Gly-Ile-Ala-Gly-Gln
Medchemexpress LLC Z-VRPR-FMK TFA | 1926163-57-6 | MFCD18782585 | 95.9% | 790.81 | 100 UG
Z-VRPR-FMK (TFA) (VRPR), a tetrapeptide, is a selective and irreversible MALT1 (Mucosa-associated lymphoid tissue lymphoma translocation protein 1) inhibitor. It can protect against influenza A virus (IAV) infection.
- Selective and irreversible MALT1 inhibitor
- Tetrapeptide
- Protects against influenza A virus (IAV) infection
Medchemexpress LLC Norleual TFA | 99.9% | 888.97 | 1 MG
Norleual TFA is an angiotensin (Ang) IV analog and a hepatocyte growth factor (HGF)/c-Met inhibitor with an IC50 of 3 pM. It acts as an AT4 receptor antagonist and demonstrates potent antiangiogenic activities. It significantly reduces HGF-dependent c-Met and Gab1 phosphorylation and attenuates HGF-dependent c-Met activation and downstream signaling. In vivo, Norleual TFA suppresses pulmonary colonization by B16-F10 murine melanoma cells.
- Reduces HGF-dependent c-Met and Gab1 phosphorylation
- Attenuates HGF-dependent c-Met activation and downstream signaling
- Inhibits HGF-dependent signaling, proliferation, migration, and invasion in multiple cell types
- Suppresses pulmonary colonization by B16-F10 murine melanoma cells
Medchemexpress LLC D2A21 TFA | >95.6% | 2775.42 | 1 MG
D2A21 TFA is an antimicrobial peptide that exhibits significant activity against Pseudomonas and has a bactericidal effect on burn scabs. This peptide also demonstrates antitumor activity, making it a candidate for research in prostate cancer.
- Antimicrobial peptide
- Active against Pseudomonas
- Bactericidal effect on burn scabs
- Antitumor activity
- Used in prostate cancer research
Medchemexpress LLC Lysylcysteine TFA | 97.8% | 477.38 | 25 MG
Lysylcysteine TFA (L-Lysyl-L-cysteine TFA) is a dipeptide composed of lysine and cysteine, intended for research use only. It is not for human use. This product is provided as a white to off-white solid with a high purity of 97.84% and a molecular weight of 477.38. It is shipped at room temperature in the continental US and requires sealed storage away from moisture.
- High purity: 97.84%
- Molecular weight: 477.38
- Dipeptide composed of lysine and cysteine
- Appearance: White to off-white solid
- Sequence: Lys-Cys
- Storage for powder: -80°C for 2 years, -20°C for 1 year
- Storage in solvent: -80°C for 6 months, -20°C for 1 month
Medchemexpress LLC DOTA-ADIBO TFA | 1374865-01-6 | 99.1% | 776.76 g/mol | C36H43F3N6O10 | 5 MG
DOTA-ADIBO TFA is a DOTA-derived bifunctional chelator supplied as the trifluoroacetic acid salt. It enables biomolecule conjugation via strain-promoted, copper-free azide-alkyne cycloaddition and supports construction of fusion chelator systems for radiometal labeling and PET radiotracer synthesis. The compound is provided as a high-purity solid with DMSO solubility and requires protected, low-temperature storage.
- DOTA-derived bifunctional chelator for copper-free click conjugation.
- Facilitates radiometal labeling for PET radiotracer synthesis.
- High reported purity suitable for research applications.
- Soluble in DMSO (≈100 mg/mL); may require sonication.
- Store under nitrogen, protect from light, keep at low temperatures.
- Provided as a TFA salt to aid handling and stability.
Medchemexpress LLC MIP-1095 (TFA) | 99.8% | 678.35 | 25 MG
MIP-1095 TFA (RPS-001 TFA) is a potent inhibitor of PSMA, demonstrating good biodistribution and efficient targeting of tumor lesions. It is utilized as an imaging probe to identify and monitor tumor progression, particularly when isotopically labeled with 131I. This labeling results in 131I-MIP-1095 showing higher renal uptake in mice.
- Potent inhibitor of PSMA
- Good biodistribution
- Efficient targeting of tumor lesions
- Can be isotopically labeled as an imaging probe
- Higher renal uptake in mice when labeled with 131I
- Used as an imaging probe to indicate tumor progression
Medchemexpress LLC Colivelin TFA | 2803948-60-7 | 99.8% | 2759.12 | 5 MG
Colivelin TFA is a brain-penetrant neuroprotective peptide and a potent activator of STAT3. It suppresses neuronal death in vitro and offers long-term benefits against neurotoxicity, Aβ deposition, neuronal apoptosis, and synaptic plasticity deficits in neurodegenerative disease. It has potential for treating Alzheimer's disease and ischemic brain injury.
- Suppresses neuronal death and activates neuroprotection through Ca2+/calmodulin-dependent protein kinase IV and STAT3 pathways.
- Reverses caspase3, Bax, and Bcl-2 expressions.
- Increases p-STAT3 protein levels.
- Suppresses spatial working memory impairment and antagonizes hippocampal neuronal loss.
- Improves motor/cognitive function and reduces lesion volume/neurological deficits post-MCAO.
- Protects against cholinotoxin-induced amnesia and ischemic brain injury.
Medchemexpress LLC WP9QY (TFA) | 199999-60-5 | 98.7% | 1340.40 | 25 MG
WP9QY TFA is a biologically active cyclic peptide, serving as a TNF-α Antagonist. It is designed to mimic the critical tumor necrosis factor (TNF) recognition loop on TNF receptor I, preventing interactions of TNF with its receptor. This peptide is a useful template for developing small molecular inhibitors to prevent inflammatory bone destruction and systemic bone loss in rheumatoid arthritis. It is for research use only.
- Biologically active peptide
- TNF-α antagonist
- Mimics critical tumor necrosis factor recognition loop on TNF receptor I
- Prevents TNF interactions with its receptor
- Useful template for small molecular inhibitor development
- Prevents inflammatory bone destruction
- Prevents systemic bone loss in rheumatoid arthritis
- For research use only