Trifluoroacetic Acid
Trifluoroacetic acid is a corrosive organofluorine compound that is structurally analogous to, but stronger than, acetic acid. Available in various quantities and reagent grades, it is used in NMR spectroscopy, mass spectrometry, organic synthesis, etc.
Almost 100,000-fold more acidic than acetic acid, TFA is widely used in organic chemistry. TFA is used as a reagent in organic synthesis because of its properties: volatility, organic solvent solubility, and acidic strength. It is less oxidizing than sulfuric acid and is more readily available in its anhydrous form than some other acids . Other features include:
- Used in acid-catalyzed reactions, especially peptide synthesis (to cleave esters)
- Dissolves protein when mixed with liquid SO2
- Removes t-butyl derived side-chain protecting groups in Fmoc peptide synthesis
- Can remove the t-butoxycarbonyl protecting group in organic synthesis
- At low concentrations, acts as an ion-pairing agent for peptides and small proteins in organic compound liquid chromatography
- For acid-stable materials, can be a solvent for NMR spectroscopy
- Acts as a calibrant in mass spectrometry
- Used to produce trifluoroacetate salts
- An ingredient in adhesives, sealants, paints, and coatings
When TFA combines with bases and metals, especially light metals, a strong exothermic reaction occurs. When mixed with lithium aluminum hydride (LAH), the reaction is explosive.
Although nonflammable, TFA is corrosive to skin, eyes, and mucous membranes and requires careful use and handling. It is harmful when inhaled, causes severe skin burns and eye damage, and is toxic to aquatic organisms at even low concentrations.
TFA is also a product of the metabolic breakdown of the anesthetic agent halothane. It is the suspected cause of halothane-induced hepatitis.
Medchemexpress LLC MC-VC-PAB-NH2 TFA | 1616727-21-9 | MFCD00935992 | 99.9% | 772.77 | C33H47F3N8O10 | 5 MG
MC-VC-PAB-NH2 TFA is a cleavable antibody-drug conjugate (ADC) linker used to attach cytotoxic payloads to antibodies and enable intracellular release through enzymatic cleavage. It contains a valine-citrulline dipeptide and a para-aminobenzyl self-immolative spacer and is supplied as the trifluoroacetate salt for stability in research applications.
- Cleavable valine-citrulline linker for cathepsin-mediated payload release.
- Para-aminobenzyl self-immolative spacer to facilitate efficient drug release.
- Supplied as a trifluoroacetate salt for improved stability and handling.
- High purity suitable for research use.
- Soluble in DMSO at high concentration; ultrasonic assistance may be required.
- Store sealed, away from moisture and light; follow recommended low-temperature storage for solutions.
Medchemexpress LLC NLS-StAx-h TFA | 2872559-21-0 | 98.9% | 3559.28 | 100 UG
NLS-StAx-h TFA is a selective, cell-permeable, stapled peptide Wnt signaling inhibitor with an IC50 of 1.4 μM. It efficiently inhibits β-catenin-transcription factor interactions and demonstrates anti-proliferation effects on cancer cells, making it suitable for research into Wnt signaling pathways.
- Efficiently inhibits β-catenin-transcription factor interactions
- Shows anti-proliferation effects on cancer cells
- Reduces the viability of SW-480 and DLD-1 colorectal cancer cells by more than 80%
- Inhibits the migration of colorectal cancer cells in a dose-dependent manner
Medchemexpress LLC Goralatide TFA | 1796568-94-9 | 98.0% | 1 MG
Goralatide TFA is an inhibitor of cell cycle progression that enhances the selectivity of hyperthermic purging of human progenitor cells. It has potential for research related to leukemia.
- Inhibits cell cycle progression.
- Enhances selectivity of hyperthermic purging of human progenitor cells.
- Potential for leukemia research.
Apexbio Technology LLC GR 94800 TFA 5mg
GR 94800 TFA is a selective antagonist targeting neuropeptide Y (NPY) Y2 receptors Neuropeptide Y signaling via Y2 receptor subtypes participates in energy balance appetite modulation mood regulation anxiety-related behaviors and neuronal response to stress GR 94800 TFA specifically inhibits NPY Y2 receptor-mediated signaling thereby facilitating studies on the physiological and behavioral outcomes regulated by this receptor pathway It is commonly utilized by biomedical researchers investigating functions of NPY systems in feeding control emotional responses anxiety and depressive behaviors as well as cognition-related processes such as learning and memory Additionally this compound serves as an investigative tool to elucidate downstream signaling pathways and potential pharmacological targets linked to the Y2 receptor
Medchemexpress LLC ALX-1393 TFA | 949164-09-4 | 99.8% | 509.45 | 50 MG
ALX-1393 TFA is a selective glycine transporter-2 (GlyT2) inhibitor that demonstrates an antinociceptive effect, meaning it helps reduce pain. This compound has been observed to alleviate pain responses to thermal, mechanical, and chemical stimulations in a rat acute pain model. In experimental settings, administration of the compound has been shown to suppress the late-phase response in the formalin test and inhibit mechanical and cold hyperalgesia in a dose-dependent manner, without affecting motor performance in normal rats.
- Selectively inhibits a specific neuronal transporter.
- Exhibits pain-reducing effects across various types of pain stimuli.
- Effective in inflammatory and neuropathic pain models.
- Does not impair motor function.
Medchemexpress LLC OS-2966 5mg | 5mg
OS-2966 is a humanized antibody expressed in CHO cells targeting Integrin b1/ITGB1/CD29 OS-2966 carries a huIgG1 type heavy chain and a hu type light chain with a predicted molecular weight (MW) of 145 5 kDa The isotype control for OS-2966 can be referenced as Human IgG1 kappa Isotype Control (HY-P99001)
Medchemexpress LLC ALX-1393 TFA | 99.8% | 509.45 | 25 MG
ALX-1393 TFA is a selective GlyT2 inhibitor that demonstrates an antinociceptive effect against thermal, mechanical, and chemical stimulations in a rat acute pain model.
- Selective GlyT2 inhibitor
- Exhibits an antinociceptive effect on thermal, mechanical, and chemical stimulations in a rat acute pain model
Medchemexpress LLC Cn2 toxin TFA | 96.59% | 7588.60 | 5 MG
Cn2 toxin TFA (β-Mammal toxin Cn2 TFA) is a single-chain β-scorpion neurotoxic peptide identified as the main toxin found in scorpion venom. It specifically targets mammalian voltage-gated sodium channels (VGSC) Nav1.6.
- Single-chain β-scorpion neurotoxic peptide
- Main toxin in scorpion venom
- Specifically targets mammalian voltage-gated sodium channels (VGSC) Nav1.6
- Available in various quantities
- For research use only
Medchemexpress LLC Phrixotoxin-1 TFA | 96.5% | 3548.30 | 1 MG
Phrixotoxin-1 TFA is a specific peptide inhibitor of the Kv4 potassium channel, derived from the venom of the theraphosid spider *Phrixotrichus auratus*. It is intended for research use only.
- Purity of 96.5%
- Molecular weight of 3548.30 (free base)
- Appears as a solid, white to off-white powder
- Solubility in H2O: ≥ 100 mg/mL
- Powder storage at -80°C for 2 years or -20°C for 1 year
- Storage in solvent at -80°C for 6 months or -20°C for 1 month
- Functions as a potassium channel inhibitor
Medchemexpress LLC Ala-MPSD TFA | 98.02% | 3016.76 | 5 MG
Ala-MPSD TFA is a control peptide for MPSD (HY-P10471). In Ala-MPSD TFA, the four serine residues of MPSD are substituted by alanines.
- Control peptide for MPSD (HY-P10471)
- Four serine residues of MPSD are substituted by alanines
- Molecular formula: C147H243N41O27.XC2HF3O2
- Sequence: Lys-Lys-Lys-Lys-Lys-Arg-Phe-Ala-Phe-Lys-Lys-Ala-Phe-Lys-Leu-Ala-Gly-Phe-Ala-Phe-Lys-Lys-Asn-Lys-Lys
- Purity: 98.02% (HPLC)
- Appearance: White to off-white (solid)
- MS consistent with structure
Medchemexpress LLC Hexa-His TFA | 1456728-20-3 | 99.8% | 954.87 | 25 MG
Hexa-His TFA is a peptide consisting of 6 His residues, used as a metal binding site for the recombinant protein.
- Consists of 6 His residues
- Used as a metal binding site
- Suitable for recombinant protein applications
- Molecular weight of 954.87
- Purity of 99.8%
- Appearance is solid, white to off-white
- Recommended storage for powder: -80°C for 2 years or -20°C for 1 year
- Recommended storage in solvent: -80°C for 6 months or -20°C for 1 month
- Store sealed and away from moisture
Medchemexpress LLC Peptide5 TFA | 98.9% | 1509.60 | 1 MG
A connexin 43 mimetic peptide, it reduces animal swelling, astrogliosis, and neuronal cell death after spinal cord injury. It also inhibits NLRP3 inflammasome, and is an anti-inflammatory agent.
- Reduces animal swelling after spinal cord injury.
- Reduces astrogliosis after spinal cord injury.
- Reduces neuronal cell death after spinal cord injury.
- Inhibits NLRP3 inflammasome.
- Acts as an anti-inflammatory agent.
Medchemexpress LLC Gmprga Tfa | 98.1% | 587.69 | 1 MG
GMPRGA (TFA) is the trifluoroacetate salt form of GMPRGA, a compound that plays a role in bacterial processes. It is known for its ability to recognize spAimR within the bacterial cytosol, which subsequently induces lysogeny. This product is intended for research applications only and is not suitable for human use.
- Recognizes spAimR in the bacterial cytosol.
- Induces lysogeny in bacteria.
- For research purposes only.
Medchemexpress LLC Zifanocycline trifluoroacetate | 00-00-0 | 99.8% | 666.64 g/mol | C31H37F3N4O9 | 5 MG
Zifanocycline TFA is an orally active, semi-synthetic aminomethylcycline antibiotic supplied as the trifluoroacetate salt for research use. It inhibits bacterial ribosome function and demonstrates broad-spectrum in vitro activity against Gram-positive and Gram-negative bacteria, including multidrug-resistant strains. Supplied at high purity for laboratory studies and antimicrobial research applications.
- Orally active aminomethylcycline antibiotic.
- Broad-spectrum activity against gram-positive and gram-negative bacteria.
- Useful for studying skin infections, community-acquired pneumonia, and intra-abdominal infections.
- High purity, suitable for analytical and biological assays.
- Provided as the trifluoroacetate (TFA) salt for improved handling.
- Molecular weight 666.64 g/mol.